Abstract

DESIGN & CHARACTERIZATION OF OSMOGRANULES OF TIMOLOL MALEATE

B. Nagarani and Rozeena Nigar*

ABSTRACT

The purpose of this study was to design and evaluate osmogranules of Timolol Maleate. Timolol Maleate is an oral antihypertensive agent which belongs to BCS class II drug with half life of 4 hours. Main objective to formulate this system was to achieve zero order release. The present study was also aimed to develop a system that would reduce the frequency of dosing and thus increases patient compliance. Poly ox polymers were used to control the drug release. All the post compression and precompression parameters showed within limits. Selected formulation F2 having Polyox N-80 73.5% successfully retarded drug release for 24hrs and drug release follows Zero order kinetic with R 2 value of 0.987. The Korsmeyer Peppas equation showed the R2 value to be 0.918 and n value was 0.639 following Zero Order & Anomalous (NonFickian Diffusion).

Keywords: Osmogranules, Poly ox, Zero order, and Korsmeyer-Peppas equation.