Abstract

EFFICACY OF PHENYTOIN SODIUM POWDER IN THE WOUND HEALING EFFECT ON DIABETIC FOOT ULCER BY LOCAL APPLICATION

Raja Soundara Pandian.P*, Madhavan Mallayasamy

ABSTRACT

To evaluate the efficacy of phenytoin sodium powder in the wound healing effect on diabetic foot ulcer by local application. The effect of phenytoin sodium powder by local application in 20 diabetic foot ulcer patients with various grade, depending on wager classification. A prospective study was done on 20 patients who fulfilled the inclusion criteria and had diabetic foot. The study was done in the surgery Department of Rajah Muthiah Medical College and Hospital (RMMCH) a 1210 bedded multi specialty teaching hospital attached to the Annamalai University. Wound healing capacity of phenytoin was evaluated for a period of six months. Emphasizing on the safety and cost Benefit. Males had more predominant incidence of diabetic foot ulcer than females [Male (75%) Female (25%)]. Topical Phenytoin was known to trigger granulation tissue and there by accelerating the wound healing on an average of 24 days, out of the 20 patients subjected 13 patients showed good wound healing effect (65%), 5 patients showed moderate wound healing effect (25%) 2 patients showed poor wound healing effect (10%) The study conducted its clearly evident that topical phenytoin sodium powder showed good wound healing effect and nor did it cause any adverse effects. Treatment of Diabetic Foot ulcer with topical phenytoin is very cost effective and safe. The topical phenytoin shows accelerated wound healing thereby decreasing the hospital stay of the patient and reduces the expenditure in health care.

Keywords: Diabetic foot, phenytoin sodium, wound healing, granulation tissue, skin grafting.