Abstract

FORMULATION AND EVALUATION OF ACARBOSE TRANSFERSOMES

Arib Rafique Shaikh*, Satkar Prasad and Gaurav Dubey

ABSTRACT

Poor patient compliance is a frequent problem in daily clinical practice. The unfavorable pharmacokinetic of the drug, the inconveniences of the standard form of such drug application and the side effects due to the administration route often are the reasons for this. Consequently much effort has been put into the development of strategies that could improve the patient compliance with new modes of drug application. Delivery via the transdermal route is an interesting option in this respect because transdermal route is convenient and safe This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half-life drugs, improving physiological and pharmacological response, avoiding the fluctuation in drug levels, inter-and intra-patient variations, and most importantly, it provides patient convenience. The present study was undertaken to explore the encapsulation of Acarbose, to characterize the transfersome for various physiochemical properties and their utility in diabetic treatment after topical administration. the present study was undertaken to explore the encapsulation of Acarbose, to characterize the transfersome for various physiochemical properties and their utility in diabetic treatment after topical administration.

Keywords: Patient compliance, conventional, Acarbose.