Abstract

RENOPROTECTIVE EFFECT OF DIOSGENIN AGAINST GENTAMICIN INDUCED KIDNEY DAMAGE ON WISTAR RATS

Dr. K. Balamurugan*

ABSTRACT

Diosgenin (DG) is a naturally occurring steroidal saponins present in variety of plants including Fenugreek [Trigonella foenum graecum] and roots of Wild Yam [Dioscorea villosa]. In the current research the renoprotective effect of Diosgenin (DG) in Wistar rats against gentamicin induced kidney damage was studied. The results revealed that the Gentamicin (80 mg/kg, i.p.) treated rats body weight of was significantly lower than the CMC suspension treated rats. In rats the DG (100 mg/kg, p.o.) treated showed increased the body weight. In biochemical estimation, gentamicin alone treated rats, showed significant decrease in total protein content and an increase in serum creatinine, serum urea, serum uric acid, and blood urea nitrogen (BUN) as compared to control rats, DG along with gentamicin treated rats resulted in a significant increase in total protein content and a decrease in serum creatinine, urea, uric acid, and BUN. In histopathological examination, compared to gentamicin-treated rats, DG decreased the severity of the gentamicin-induced renal necrotic damage by reducing the histopathological damages.

Keywords: serum creatinine, urea, uric acid, and BUN.