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DEVELOPMENT AND VALIDATION OF UV, FIRST-ORDER DERIVATIVE, SECOND ORDER DERIVATIVE AND AREA UNDER CURVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF NAPROXEN IN BULK MATERIAL AND IN TABLETS
Dr. Ravindra Y. Patil, Dr. Vijaya Uday Barge*, Sharmila Deepak Kuskar, Sushama Vishwanath Patil
ABSTRACT In the present work, sensitive spectrophotometric method has been developed for the quantitative estimation of naproxen. Methanol was selected as a common solvent for estimation of naproxen. Ultraviolet (UV), first derivative, second derivative, and AUCspectrophotometric methods for the determination of naproxen in pharmaceutical formulations have been developed. λmax for naproxen was found to be 231nm. The linearity range was found to be 0.5-3 μgml–1 in methanol and the regression equation was y = 0.369x + 0.062 (r2=0.999). The methods were validated by following the analytical performance parameters suggested by the International Conference on Harmonization (ICH). All validation parameters were within the acceptable range. The developed methods were successfully applied to estimate the amount of naproxen in pharmaceutical formulations. Keywords: AUC-spectrophotometry, derivative-spectrophotometry, naproxen, UV spectrophotometry. [Download Article] [Download Certifiate] |