Abstract

A REVIEW ARTICLE ON PATHOLOGICAL MECHANISM OF DIABETIC NEPHROPATHY

Qumre Alam*, Amarjeet Singh, Akash Johri, AmanPandit

ABSTRACT

Diabetic nephropathy is correlated with enhanced mortality in diabetic patients and in most of the countries it was the significant reason for renal failure. As a consequence of an association between hemodynamic and metabolic factors, diabetic nephropathy appears to happen. In the diabetic kidney, the glucose- dependent pathway is triggered. These include enhanced oxidative stress and sophisticated glycated end-product accumulation. Hemodynamic factors are also involved in diabetic nephropathy pathogenesis and include enhanced blood related and kidney glomerulus stress and trigger the multiple pathways of vasoactive hormones including rennin-angiotensin and endotheline. This review is aimed at bringing together the present updated mechanism engaged in diabetic nephropathy pathogenesis.

Keywords: Diabetic nephropathy, Endothelin, Rennin-angiotensin, Nephrin.