Abstract

REVIEW ON TECHNIQUES OF SOLUBILITY INHANCEMENT

Pratik D. Vaidya*, Snehal Y. Chakre, Akshay N. Gudadhe and Akash P. Mhala

ABSTRACT

Solubility is a crucial aspect that influences the medication's effectiveness. Poor solubility of a medicine in systemic circulation is caused by a number of factors. Therefore, a variety of methods are employed to increase solubility. This method allows for the desired systemic circulation of the medication. Unsatisfactory bioavailability is frequently caused by the poorly water soluble drug molecules in the gastrointestinal fluid. Any medicine that is to be absorbed must be present at the site of absorption in the form of an aqueous solution, and poorly aqueous soluble pharmaceuticals frequently require substantial dosages to reach therapeutic plasma concentrations following oral administration. Any medicine that is to be absorbed must be present in solution at the absorption site. Particle size reduction, crystal engineering, salt creation, solid dispersion, use of surfactants, complexation, and other techniques are used to increase the solubility of poorly soluble pharmaceuticals. These techniques include physical and chemical drug changes as well as additional approaches. The choice of a solubility improving technique depends on the drug's properties, the site of absorption, and the requirements for the dosage form. Different methods are employed to increase solubility.

Keywords: Solubility, Medicine, Technique, Absorbe, Improving, Solid, Administration.