Abstract

TRANSFEROSOMES: AN ADVANCED NOVEL TECHNIQUE FOR TRANSDERMAL DRUG DELIVERY

Aman Kumar Choudhury*, Riane Saha and Dr. L. Srinivas

ABSTRACT

The development of innovative medicine delivery methods is currently generating renewed interest. These innovative medication delivery technologies also include vesicular drug delivery system. Skin permeability, or TDDS, is extremely impermeable to macromolecules and hydrophilic medicines but permeable to small molecules and lipophilic medications. Recent methods have led to the creation of two vesicular carriers: ethosomes and transferosomes, which are incredibly elastic lipid-based vesicles. Transferosomes can pass both high & low molecular weight medications transdermally.This has been used to enhance the efficiency of material transferring across skin intact by the use of sonophoresis, colloidal carriers, among other methods. These methods have a number of main advantages over convenient routes, including the avoidance of the first pass metabolism, the predictable and the extended duration of the activity, minimization of undesired side effects, improved pharmacological response, minimization of undesirable side effects. It allows for better intact vesicle penetration because of its high deformability. Because they may formed of naturally occured phospholipids and have a high efficiency entrapment, they may biocompatible and biodegradable. The preparation process was correspondingly refined and validated because the preparation factors depend on the manufacturing process used to make the formulation. It is possible to characterise transferosomes to learn about their drug content, entrapment effectiveness, size, morphology, ability to penetrate, in vitro drug release, the occlusion effect, surface charge. This improves the stability of the labile drugs and offers controlled release.

Keywords: Novel Drug Delivery System, Optimisation, Transdermal drug delivery system, Transferosomes.