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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

PREPARATION AND THERMAL BEHAVIOUR OF UREA-VANILLIN CO-CRYSTAL

Fouzia Rafat*

ABSTRACT

The objective of this study was to screen and prepare co-crystal of urea and vanillin. In the bulk scale of crystallization, urea-vanillin (U-V) co-crystals have been synthesized by solid grinding method and slow evaporation in ethanol. Urea forms co-crystal with a 1:1 stoichiometric ratio with vanillin. Screening was performed by thermogravimetric analysis and differential scanning calorimetry. The properties of solids have been altered under confinement such as melting point, dissolution and thermal stability. The difference in melting point between the urea or vanillin and the co-crystal was studied. The melting point of urea were previously high but decreased after formation of co-crystal with vanillin.

Keywords: Co-crystal, TGA, DSC, Crystallization, Grinding.

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