Abstract

FORMULATION, EVALUATION AND OPTIMIZATION OF FAST DISSOLVING ORAL FILM OF SELECTIVE ANTIHYPERTENSIVE DRUG

Pallavi Patil.* and S.K. Shrivastava

ABSTRACT

Fast dissolving oral drug delivery system are solid dosage form which disintegrate or dissolve within second when placed in the mouth without need of water or chewing, first developed fast dissolving dosage form consisted in tablet form and the rapid disintegrating properties were obtained through a special procedure or formulation modification, recently fast dissolving film are gaining interest as an alternative to fast dissolving tablet to eliminate fear of chocking. In present investigation, an attempt has been made to develop oral fast dissolving film of Metoprolol Tartrate (25mg), the film were prepared by solvent casting method in which solution was casted on glass surface by using film forming machine, the characterization of film was done by evaluating various film forming polymer and plasticizer, concentration of polymer and plasticizer were optimized by evaluating various physical and chemical properties of film , Metoprolol Tartrate ODF contain HPMC E5 as a polymer, Sucralose as a sweetener and glycerol as a plasticizer proves to be potential, various concentration of HPMC E5 and glycerol ODF formulation were made and various mechanical properties were analyzed, formulation consisting HPMC E5 and glycerol were proving to be better ODF formulation , mechanical property of film like disintegration time, folding endurance were compared with marketed products like ONDEM OF , stability study done by comparing dissolution profile of fresh and stability sample.

Keywords: Fast dissolving film, Dysphagia, Pediatric, Hydrophilic polymers.