Abstract

IMPORTANT METHODS OF SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF 1, 2, 4-TRIAZOLE DERIVATIVES

Rakesh Singh*, Dr. Anuja Chouhan

ABSTRACT

In the last few decades, several five membered heterocyclic compounds such as triazoles have been studied extensively owing to their interesting biological activities such as antimicrobial, antiviral, antitumor, anticonvulsant, antifungal etc. The five membered triazole ring exists in two isomeric forms i.e. 1, 2, 3-triazole and 1, 2, 4- triazole.The five membered 1, 2, 4-triazole ring exists in two tautomeric forms i.e. 1H-1, 2, 4-triazole, 4H-1, 2, 4-triazole collectively known as s-triazoles. The s-triazole derivatives possess extensive spectrum of biological activities such as antibacterial, antifungal, antitubercular, anxiolytic, anticonvulsant, anti-inflammatory, analgesic, anticancer, antioxidant activities. This diversity in the biological activity of 1,2,4-triazoles has attracted the attention of many researchers to explore this skeleton for its wide potential against several activities. This review contains various methods of synthesis of 1, 2, 4-triazole derivatives and their pharmacological activities .

Keywords: 1,2,4-Triazole, Methods of synthesis, Antibacterial, Antifungal, Antiinflammatory, Anticancer, Anticonvulsant, Antioxidant, Antidepressant