REVIEW ON CONTROLLED RELEASE FOR LOCAL DELIVERY OF DRUGS: BARRIERS AND MODELS
*Rupali H. Chavhan, Snehal Y. Chakre, Pravin B. Bhoyar, Pooja D. Dadmal, Dipali M. Shende and Neha D. Chavat
ABSTRACT
Controlled release systems are an effective means for local drug
delivery. In local drug delivery, the major goal is to supply therapeutic
levels of a drug agent at a physical site in the body for a prolonged
period. A second goal is to reduce systemic toxicities, by avoiding the
delivery of agents to non-target tissues remote from the site.
Understanding the dynamics of drug transport in the vicinity of a local
drug delivery device is helpful in achieving both of these goals. Here,
we provide an overview of controlled release systems for local delivery
and we review mathematical models of drug transport in tissue, which
describe the local penetration of drugs into tissue and illustrate the
factors—such as diffusion, convection, and elimination—that control
drug dispersion and its ultimate fate. This review highlights the
important role of controlled release science in development of reliable methods for local
delivery, as well as the barriers to accomplishing effective delivery in the brain, blood vessels,
mucosal epithelia, and the skin.
Keywords: Controlled release, pharmacokinetics, polymer systems, local delivery, wound healing.
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