Abstract

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF SELFNANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) OF NATEGLINIDE

KishorSagar*,PrakashKendre, Vishal Pande, VaibhavChaudhari

ABSTRACT

Poor water solubility and dissolution rate are issues for the majority of upcoming and existing biologically active compounds. In the present investigation an attempt was made to enhance the solubility and dissolution of poorly soluble drug, Nateglinide, by formulating selfnanoemulsifying drug delivery systems (SNEDDS).Phase solubility of Nateglinide was evaluated in various non-aqueous carriers that included oils, surfactants, and co-surfactants. Pseudo ternary phase diagrams were constructed to identify the optimized selfnanoemulsification region. Preliminary screening was carried out to select proper components combination i.e. oil, surfactant and cosurfactant respectively. Nateglinide SNEDDS was prepared by using Capmul MCM C-8 (oil), Cremophor EL (surfactant), and Transcutol HP (co-surfactant).Two different adsorbents with high specific surface areas were used i.e.NeusilinUS2, NeusilinUFL2 (magnesium aluminometasilicate).The formulations were characterized for self-emulsification assessment, globule size, polydispersity index, zeta potential, % transmittance, drug content, thermodynamic stability and in-vitro dissolution study. The optimized Nateglinide SNEDDS composed of 20.23% Capmul MCM C-8, 55.77% Cremophor EL and 23 % Transcutol HP. The rate of dissolution of optimized SNDDES showed better result(91.12%) in 35 min when compared with marketed tablet 72.3% and pure drug (32.54%).The results from this study demonstrate the potential use of SNEDDS in enhancing solubility and dissolution rate of Nateglinide.

Keywords: Nateglinide, SNEDDS, pseudo ternary Phase diagram, dissolution rate, NeusilinUS2 etc.