Abstract

BUOYANT OIL ENTRAPPED GASTRO RETENTIVE MULTIPARTICULATE CALCIUM PECTINATE GEL BEADS OF CEFIXIME

Naveen Kumar Bommagani*, Mounika.Basani, Dr.S Vasudeva Murthy

ABSTRACT

The gastroretentive sustained release system of cefixime was formulated to increase the gastric residence time and modulate its release behaviour. Olive oil entrapped beads containing cefixime capable of floating in the gastric condition were formulated and evaluated. Cefixime is a third generation cephalosporin antibacterial agent which results from inhibition of mucopeptide synthesis in the bacterial cell wall. Cefixime is considered as a suitable drug candidate for floating controlled drug delivery system. Hence, cefixime beads were prepared by emulsion gelation method by employing pectin and sodium alginate as sustained release polymers in three different ratios and olive oil was used to enable floating property to the beads. The effect of validation in polymer and their concentration was investigated. The beads were evaluated for production yield, particle size, swelling index, density measurement, in-vitro buoyancy, drug content, drug entrapment efficiency, in-vitro release characteristics, and in-vitro release kinetic study. Based on drug entrapment efficiency, buoyancy, swelling and in-vitro release, F9 was selected as the optimized formulation. F9 was further subjected to surface morphology by SEM. In-vivo floating study in rabbits was performed and revealed that the beads were floating in the rabbit stomach upto 10h. In-vitro release follows first order and fitted in Higuchi model with a Fickian diffusion mechanism according to Korsemeyer- Peppas(n=0.389). Therefore, the rate of drug release is due to drug diffusion from a polymer system. Thus, it was concluded that the sustained release formulation containing cefixime was found to improve patient compliance, minimize side effects, and decrease the frequency of administration.

Keywords: Cefixime, Floating drug delivery system, Sodium alginate, olive oil, oil entrapped floating bead