![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
PREPARATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF ZOLPIDEM TARTARATE USING HYDROGEL POLYMERS
Mohammed Asadullah Jahangir*, Mohammed Shadab Shahab, M. A. Saleem, Abdul Muheem, Kamran Ahmad, Dr. Imran Kazmi
ABSTRACT
In the present investigation, an attempt was made to develop a sustained release matrix tablet of Zolpidem tartrate by direct compression technique using hydrogel forming natural polysaccharides such as sodium alginate, xanthan gum, guar gum and chitosan alone and in combination with chitosan in varying concentration. The Fourier Transform Infrared spectroscopic study revealed no major interaction between drug and polymer. All the pre-compression parameters for drug polymer mixture and post compression parameters of the tablet were in the acceptable range of pharmacopoeial specifications. The prepared matrix tablets showed good swelling from 343 to 758% in 12 hours, maintaining integrity of the formulation in rank order of polymer taken alone xanthan gum > sodium alginate > guar gum > chitosan. The in vitro dissolution studies of Zolpidem tartarate matrix tablet was carried out in USP apparatus I and the release was found to be 80 to 90% for an extended period of 10 to 12 hours. The release data was fitted to various mathematical models such as Higuchi, zero order, first order, Korsmeyer-peppas model and it was found that the in vitro release obeyed first order kinetics with release mechanism being diffusion controlled. The stability studies were carried out according to ICH guidelines which confirmed that the formulations are stable. Keywords: Zolpidem tartarate, sustained release, chitosan, xanthan gum, sodium alginate, guar gum. [Download Article] [Download Certifiate] |