Abstract

THIADIAZOLE DERIVATIVES A POTENT COMPOUND AGAINST MYCOBACTERIUM TUBERCULOSIS

Surya Prakash, Kuldeep Singh*, Shivendra Kumar, Sunam Saha, Anurag and Abhishek Kashyap

ABSTRACT

The most lethal infectious illness in the world, tuberculosis (TB), claims millions of lives each year. New treatment alternatives are desperately required since various pathogenic strains of Mycobacterium tuberculosis (M. TB) have become resistant to the most recognized anti-TB medications. Since glutamine synthase is essential for mycobacterial survival, it is a prime candidate to be the target of novel antitubercular drugs. Thidiazole has a solid potential to inhibit glutamine synthase I. The proposed molecule was docked to a target using autodock4 and reactants that included 4-(benzyloxy) benzaldehyde, cinnamaldehyde, and 3-nitro benzaldehyde. BOB, CIN, and NIB were also produced. Additional structural changes to produced compounds may aid in the development of promising anti-pathogen agents.

Keywords: 4-(Benzyloxy) benzaldehyde, thiadiazole, Mycobacterium tuberculosis, glutamine synthase I, autodock4.