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A REVIEW ON BILAYER TABLET
*Pathade Abasaheb Shridhar, Prof. Dr. Pravin B. Cholke
ABSTRACT Bilayer tablets are developed to get an immediate and sustained delivery of various drugs which have pre-defined release. In past few decades, development in combination of active pharmaceutical ingredients (API) in a single fixed dosage form has increased in the pharmaceutical industry, also promotes patient convenience and compliance. Bi-layer tablet plays a crucial role for development of controlled release in order to give a successful drug delivery. Bi-layer tablets can be said to be a better option to reduce chemical incompatibilities taking place between Active Pharmaceutical Ingredients and to enable the development of various drug release profiles. Bilayer tablet suits for sequential release of two drugs in combination or to incorporate two incompatible substances in same tablet. The bilayer tablets preparing by using different techniques such as OROS® push pulls Technology, L-OROSTM Technology, EN SO TROL Technology. Bi-layer tablet is a new era for successful development of controlled release formulation along with various features to provide successful drug delivery. Bilayer layer tablets have been consist of two layers which is slow release and immediate release layer. As well as improved beneficial technology to overcome the shortcoming of the single layer tablets. The preparations of bilayer tablet were needs due to separate incompatible active pharmaceutical ingredient (APIs) for each other. Bilayer tablets material involves both the compressibility and consolidation. . Now a day’s bilayer tablets are prepared such as ―Atorvastatin, Atenolol‖, Nifedipine, ―Aspirin, Isosorbide 5-mononitrate‖, ―Pioglitazone HCl, Gliclazide‖, Losartan potassium, and ―Trimetazidine hydrochloride clopidogrel bisulphate. Keywords: Bilayer tablets, Nifedipine, Sustained release, OROS® push pulls Technology. [Download Article] [Download Certifiate] |