Abstract

HYPOLIPIDEMIC ACTIVITY OF NANOPARTICLES CONTAINING LOVASTATIN IN HYPERCHOLESTERIC ALBINO RATS

Anilkumar J. Shinde,* Harinath N. More

*Department of Pharmaceutics, Bharati Vidyapeeth, College of Pharmacy, Near chitranagari, Kolhapur. India.

ABSTRACT

The present study was carried out to study the effect of nanoparticle formulation on serum lipids in albino rats. The hypolipidemic effect was compared with a standard dose of lovastatin, control and hyperlidemic control group. The rats were divided into four groups of six animals each., viz., test treatment group (TTG), reference treatment group (RTG), control treatment group (CTG) and hyperlidemic treatment group(HTG). The treatment was given for 21 days. Each treatment group received daily standard cholesterol diet, orally in the morning throughout 21 days to induce hyperlipidemia except control treatment group. Test formulation (TF), aqueous suspensions of lovastatin (RF) administered oral dose was 1 mg per animal once a day (equivalent to 10 mg kg–1 per day). Blood samples were collected at predetermined time intervals viz., before treatment and after 5, 10, 15 and 21 days and serum cholesterol, triglycerides and high density lipoproteins were measured. Serum levels on days 10 and 21 were compared using students paired t-test (p < 0.001). The results shows that plasma CH and TG levels were significantly lower (91.70±0.04 mg/dl, 145.50±0.03 mg/dl respectively) (p < 0.001) and HDL-CH levels were significantly higher (44.65±0.02 mg/dl, p< 0.001) in TTG compared to RTG. There was a significant decrease in serum cholesterol in nanoparticle formulation than standard drug.

Keywords: Cardiovascular diseases, Lovastatin formulation, Hypolipidemic drug, Serum Cholesterol.