Abstract

STUDY ON FLOATING DRUG DELIVERY SYSTEM AS A NEW OPPORTUNITY

Mule Rajashri*, Khedkar Priyanka, Devand Pol, Ashwini Jadhav and Dr. Rajesh Oswal

ABSTRACT

Formulation of floating drug delivery system (FDDS) is a topic of current interest in pharmaceutical products development. Floating drug delivery system are low-density systems that float over the gastric content and remain buoyant in the stomach for a prolonged period of time. They enhance drug bioavailability, reduce drug wastage and provide controlled drug delivery and better patient compliance .Several approaches and techniques were developed in recent year for FDDS. Literature on FDDS along with recent research in this area is reviewed in this article. The floating or hydrodynamically controlled drug delivery systems are useful in such application. The present review addresses briefly about the floating drug delivery systems. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.

Keywords: Floating drug delivery systems, Gastric Residence.