Abstract

THE PREVALENCE OF PULMONARY TUBERCULOSIS PATIENTS WHO HAVE INDUCED HEART INJURY (DILI) IN DR. M. DJAMIL HOSPITAL, PADANG IN 2019

Lola Azyenela*, Okta Fera and Rosmelia

ABSTRACT

Tuberculosis is an infectious disease caused by bacteria, namely mycobacterium tuberculosis. Long-term use of anti-tuberculosis drugs has a side effect of hepatotoxicity which is characterized by increased levels of AST, ALT and bilirubin. The aim of this study was to determine the incidence of pulmonary tuberculosis patients who experienced Drug Induced Liver Injury (DILI) at the Dr. M. Djamil Hospital Padang in 2019. The type of this research is cross-sectional descriptive, with retrospective data collection, using primary data from medical records. The sample of this study were all hospitalized pulmonary tuberculosis patients who met the inclusion criteria, this study used patients aged over 18 years who had complete AST, ALT and bilirubin data after receiving drug therapy and pulmonary tuberculosis patients treated with antituberculosis drug at M. Djamil Hospital Padang in 2019. The sampling technique is total sampling, the method of data collection is to record the AST, ALT and bilirubin data that have received antituberculosis drug therapy compared to the normal AST, ALT and bilirubin values, the results obtained are percentages presented in tabular form. Patients diagnosed with pulmonary tuberculosis in Dr. M. Djamil Hospital Padang in 2019 had as many as 215 patients, who were included in the study inclusion criteria as many as 92 patients (42.8%). Based on AST, there were 25 patients (27.18%) who had hepatotoxicity, while the AST parameters were 17 patients (18.48%) and 11 patients (11.96%) had high bilirubin levels. The results of the study concluded that the incidence rate at the Central General Hospital Dr. M. Djamil Padang in 2019 had as many as 28 patients (30.43%).

Keywords: pulmonary tuberculosis, anti-tuberculosis drugs, Drug Induced Liver Injury, prevalence.