Abstract

CLINICAL PHARMACOLOGY OF THE AGENTS TO TREAT VIRAL HEPATITIS IN INFANTS AND CHILDREN

Pacifici Gian Maria*

ABSTRACT

The agents used to treat viral hepatitis in paediatric patients are: tenofovir alafenamide, sofosbuvir, ledipasvir with sofosbuvir, ribavirin, and glecaprevir with pibrentasvir. Tenofovir alafenamide administered to pregnant women efficacy and safe treats their infants. Tenofovir alafenamide administered to pregnant women prevents the transmission of hepatitis B virus from the mother to their infants and tenofovir/alafenamide poorly migrates into the breast-milk. Sofosbuvir, administered alone or combined to other antiviral drugs, has been found efficacy and safe in infants and children and sofosbuvir, administered alone or combined to other antiviral drugs, treats children infected by hepatitis C virus. Ledipasvir/sofosbuvir treats children infected by hepatitis C virus. Ribavirin, administered alone or combined to other antiviral drugs, treats children with respiratory syncytial viral infection, children with viral influenza A and B, and children infected by hepatitis C virus. Only one study is available for glecaprevir/pibrentasvir and this drug combination effectively treats adolescents infected by hepatitis C virus. The aim of this study is to review the dosing of tenofovir alafenamide, sofosbuvir, ledipasvir with sofosbuvir, ribavirin, and glecaprevir with pibrentasvir. Tenofovir alafenamide administered to pregnant women teats infants infected by HIV of by hepatitis B virus, prevents the transmission of hepatitis B virus from the mother to their infants, and poorly migrates into the breast-milk. Sofosbuvir treats children infected by hepatitis C virus, ledipasvir/sofosbuvir treats children infected by hepatitis C virus, ribavirin treats infants with respiratory syncytial virus infection, and children infected by hepatitis C virus and the treatment of adolescents with glecaprevir/pibrentasvir.

Keywords: Breast-milk, dosing, Efficacy-safety, Glecaprevir/Pibrentasvir, Ledipasvir/Sofosbuvir, Ribavirin, sofosbuvir, Tenofovir-Alafenamide, Treatment.