Abstract

NOVEL APPROACH FOR PREPARATION FAST DISSOLVING TABLETS OF GYMNEMA SYLVESTRE

Ruhi Fatma*, Dr. P.K. Nandi, Dr. Ajay Kumar Gupta

ABSTRACT

Gymnema sylvestre is one of the most popular anti-diabetic herb and gymnemic acid is the main active constituent responsible for hypoglycaemic activity. The atomic arrangement of gymnemic acid molecule is similar to that of glucose molecule and thus provides better control and management in type-2 diabetes. In the present study, formulation for the fast dissolving tablets of Gymnema sylvestre is developed for its quick release in the oral cavity. The formulation of G. sylvestre was prepared by using sodium starch glycolate and croscarmellose sodium as a superdisintigrants and mannitol as a sweetening agent. The Data expert software is applied for the fullfactorial design, the ANOVA study of the Linear regression model and T-test confirmed that predicted and observed response showed no significant difference. The results indicated that there is significant improvement in disintegration of the tablet and the extent of disintegration was highly dependent on the amount of the disintegrants used. Thus the study indicated that fast dissolving tablets of Gymnema sylvestre could be successfully and quickly delivered orally when formulated with the selected superdisintegrants.

Keywords: Gymnema sylvestre, Gymnemic acid, ANOVA (Analysis of variance), T-Test (Student t-test).