Abstract

HEPATOPROTECTIVE ACTIVITY OF BUTEA MONOSPERMA LEAF EXTRACTS IN CCL4 INDUCED ALBINO RATS

Annem Srinivas Reddy*

ABSTRACT

Liver is one of the vital organs in the human body. Cirrhosis, hepatitis, jaundice, liver cancer aresome of the disorders due to which the liver diminishes. The available drugsare not completely curbing the disorders and mostly, they are fetching sideeffects. Medicinal plants can combat to these problems and can be used forthe therapy. The plant Buteamonosperma collected from the village area of Gudur, Mahabubabad district. The plant leaves were dried, powdered and used for the extraction. Methanol and aqueous were used as solvents to prepare the extract through maceration technique. The albino rats weredivided into the following groups for studying the hepatoprotective activity. Group-I control, Group-II- CCL4 (1ml /kg 1:1 in coconut oil- i.p.), Group- III– CCL4+ Liv - 52 (5ml/kg), Group- IV –CCL4+ BMALF (Buteamonosperma Aqueous Leaf Extract) 200mg/kg. Group-V- CCL4+ BMALF 400mg/kg, Group-VI CCL4 +BMMLF (Buteamonosperma Methanol Leaf Extract) 200 mg/kg and Group- VII- CCL4+ BMMLF 400 mg/kg. 8 rats were maintained in each group. The treatment of the extract and liver tonic was done through oral with gastric gavages for 14 days. On 15th day the blood of the rats was collected through retro orbital plexus. The serum samples were separated for the serological tests. The serum parameters like increased bilirubin, SGOT, SGPT, ALP, LDL, VLDL, Cholesterol, triglycerides and decreased levels of protein, HDL were noticed in the CCL4 induced group-II rats. The normal levels were seen in the both extracts administered rats. Results were compared significantlywith group-III. Reformed hepatocytes in the extracts treated rats also supported the hepatoprotective activity of the extracts. The BMMLF showed better results than to the BMALF.

Keywords: CCL4, SGOT, SGPT, ALP, Hepatoprotective activity.