Abstract

AN ANALYTICAL APPROACH OF OMEPRAZOLE: A REVIEW

Prachi Shah*, Kinjal Parmar and Vaishali Patel

ABSTRACT

Omeprazole is chemically 5-methoxy-2- [[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulphinyl]-1H-benzimidazole. It is a Proton Pump Inhibitors (PPIs) used for the prevention of gastric and duodenal ulcers. The drug comprises a racemic mixture of two enantiomers. Omeprazole contains a tri co-ordinated sulphur atom in a pyramidal structure and therefore it can exist in two different optically active forms, (S)- and (R)-Omeprazole. S enantiomer having a higher bioavailability than R-Omeprazole. Omeprazole blocks acid secretion in response to all stimuli and decreasing the acid in the stomach can aid the healing of duodenal ulcers and reduce the pain from indigestion and heartburn. Omeprazole is thus activated close to its target enzyme, where it is present in high concentrations, and binds selectively to the gastric H+, K+-ATPase. Various analytical methods for the quantitative determination of Omeprazole alone or in combination in pharmaceutical formulations like UV, RP-HPLC, HPTLC, Stability of UV, Stability of RP-HPLC, LC-MS, UPLC, UFLC.

Keywords: Omeprazole, UV, RP-HPLC, HPTLC, Stability of UV, Stability of RP-HPLC LC-MS, UPLC, UFLC.