Abstract

INCLUSIVE REVIEW ON ANALYTICAL AND BIOANALYTICAL PROFILE OF GEMIFLOXACIN

Vikas Patil*, Vinay V. Sarode, Punam C. Patil, Mayuri D. Patil and Rupali R. Patil

ABSTRACT

Gemifloxacin (GFX) is fourth generation fluoroquinolone antibacterial compound. It is having enhance affinity for bacterial topoisomerase IV. It is used for the treatment of respiratory and urinary tract infection. Gemifloxacin was approved by Food and Drug Administration (FDA) in April 2003 for the treatment of acute bacterial exacerbation of chronic bronchitis, mild to moderate pneumonia, and multidrug resistance S. pneumoniae as well as community acquired pneumonia. Therefore, in the present review article, we have enlisted different analytical and bioanalytical methods such as Ultraviolet (UV) visible spectroscopy, high-performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC), ultra-performance liquid chromatography (UPLC) methods for both qualitative and quantitative analysis of GFX in pharmaceutical dosage forms and biological fluids. In the future, this review article will assist researchers regarding the development of a new analytic and bioanalytical method for GFX.

Keywords: Gemifloxicin, fourth generation fluoroquinolone, antibacterial compound, Analytical method, HPLC, UPLC, Bioanalytical methods.