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All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
REVIEW ON CLINICAL PHARMACOLOGY OF 5 – FLUOROURACIL – MECHANISM OF ACTION, RESISTANCE, TOXICITY AND CLINICAL USE
Dr. P. Sharmila Nirojini1*, N. K. Bhuvaneshwari, N. Dharsshini, S. Dhivya Bharathi
ABSTRACT
This is exactly the 60th year of 5 – Fluorouracil playing crucial role in cancer chemotherapy. Since its approval on 1962, 5 -FU has developed into a key agent in treating a wide range of tumors, including all gastrointestinal cancers, breast cancers, bladder cancers, head and neck cancers. Additionally, a novel approach to cancer chemotherapy has emerged that uses pharmacomodulation and biochemical modulation of 5-FU to boost therapeutic efficacy. Keywords: Fluorouracil, Cancer, Chemotherapy, Resistance, Toxicity. [Download Article] [Download Certifiate] |