Abstract

A REVIEW ARTICLE ON GUT - BRAIN AXIS

Aishwarya S. Gandhle*, Dr. Sameer Shafi, Priyanka S. Nilangekar, Monika D. Khichade and Sushil S. Kore

ABSTRACT

The aim of the review is to provide an overview of how person specific-interactions between diet and the gut microbiota could play a role in affecting diet induced weight loss response. The highly specific gut microbiota, which is shaped by our diet, secrete digestive enzyme and molecules that affect digestion in the colon. Therefore, weight loss responses could in part depend on personal colonic fermentation responses, which affect energy extraction of food and production of microbial metabolite, such as short – chain fatty acids (SCFAS), which exerts various effects on host metabolism colonic fermentation is the net result of the complex interplay between availability of dietary substrate, the functional capacity of the gut microbiome and environment (abiotic) factors in the gut such as pH and transit time . While animal studies have demonstrated that the gut microbiota can casually affect obesity, casual and mechanistic evidence from human studies is still largely lacking. However, recent human studies have proposed that the baseline gut microbiota composition may predict diet induced weight loss responses.

Keywords: Personalised nutrition: Gut microbiome: Obesity: Weight loss