Abstract

DEVELOPMENT AND EVALUATION OF FLOATING BILAYER TABLETS OF OMEPRAZOLE AND AMOXICILLIN

Chidananda S.P., P. Ashok Kumar*, Suresh V. Kulkarni and Manjunath K.

ABSTRACT

Bilayer floating tablets of omeprazole and Amoxicillin were developed by direct compression method. Immediate release layer contains 20 mg of drug and super disintegrant sodium starch glycolate, serves the purpose of loading dose. Sustained release layer contained HPMC K100M, natural polymers like xanthan gum, guar gum, locust bean gum, karaya gum release the drug for 12 hrs of time. Sodium bicarbonate and citric acid are used to produce effervescence. Floating lag time of optimised tablet is 92 sec, whereas floating duration is more than 12 hrs. FTIR results revealed that there was no interaction between drug and HPMC K 100M/ xanthan gum. The post compression parameters of developed tablet are satisfactory. In this study it was confirmed that the formulations containing HPMC K 100M, have shown better floating properties and finally the formulation containing a combination of HPMC K100M and Xanthan Gum in 3:1 ratio, has shown slower in-vitro drug release properties. The release kinetics of optimised formulation prepared with the combination of HPMC K100M and xanthan gum followed zero order kinetics.

Keywords: Floating bilayer tablet, Omeprazole and Amoxicillin, HPMC K 100M, Xanthan gum, FTIR.