Abstract

FORMULATION OF ARIPIPRAZOLE NANOPARTICLES BY MELT EMULSIFICATION AND LOW TEMPERATURE SOLIDIFICATION METHOD

Arun Nirmal*, Kuldeep Chaurasiya and Dr. Kapil Purohit

ABSTRACT

Present investigations were focused on formulation and evaluation of lipid solid based nanoparticles for poor water soluble drug aripiprazole. The studies included preformulation studies including but not limited to solubility, partition-coefficient, melting point, micrometric study, Infrared spectroscopy, UV-Spectroscopy. Identification and authentication of drug by UV spectrum was interpreted and absorption maxima (λmax) in scanning range of 200-400 nm was found to be at 257 nm as per specification. The solubility of the drug was tested on the basis of maximum solubility. Nanoparticles were prepared using melt emulsification and low-temperature Solidification method. Evaluation of Aripiprazole Nanoparticles was done under the different parameters like particle size, zeta potential, Polydispersity Index, Percentage Yield, Loading Efficiency, Entrapment Efficiency and surface morphology of the nanoparticle was examined by scanning electron microscopy (SEM). During in-vitro drug release study of Nanoparticless batches cumulative % of drug release was found as 62.72, 69.23, 81.23, 94.18, 85.42, 91.27, 79.79, 63.83 and 66.13 for NF-1, NF-2, NF-3, NF-4, NF-5, NF-6, NF-7, NF-8 and NF-9 respectively. Hence, F-4 and F-6 nanoparticles having drug release above 90% were selected for further kinetic study. Both preparations drug release data were fitted into the zero order, first order, Higuchi and Peppas model of drug release kinetics and found both formulations followed zero order kinetics.

Keywords: Aripiprazole, lipid-solid nanoparticles, preformulation, melt emulsification method.