Abstract

PREPARATION AND EVALUATION OF NANO-CARRIER OF ITRACONAZOLE DRUG FOR TOPICAL DELIVERY

Dharamveer Kushwah* and Dr. Atul Kaushik

ABSTRACT

Itraconazole is a broad-spectrum synthetic antifungal agent of common use for treatment of various skin infection which is specific to fungal infected cells with low toxicity and which is less toxic than earlier generation of antifungal agents and as such represents a major therapeutic advance. This drug was selected for the study because it has good percutaneous absorption and appears to be more active as antifungal activity and is well tolerated. The polymers namely compritol888ATO, polyvilyl alcohol, Carbopol-940 were used for formulation of SLN and studied for their drug release from the SLN formulations. The topical delivery of Itraconazole to the skin by means of SLNs could possibly minimize its systemic access and side effects. Furthermore, Itraconazole loaded SLNs were capable of reducing the fungal burden. Different formulations of Itraconazole were prepared by using compritol888ATO, polyvilyl alcohol, Carbopol-940 in varying proportions. SLN were prepared by micro emulsion method by using compritol, polyvilyl alcohol, Carbopol-940. FTIR studies proved no interaction between drug, polymer and formulation. In vitro drug release studies of the formulations were carried out across the synthetic membrane was investigated using the validated Franz cells. Hence drug loaded topical SLN was prepared which would be a promising drug delivery for topical application and the formulation B1 was found the most optimized.

Keywords: Nano-carrier, Itraconazole, topical delivery, percutaneous, solid lipid nanoparticles.