Abstract

FORMULATION AND EVALUATION OF NANOSPONGE

*Ms. Bushra Qureshi, Ms. Sana Sahil, Firoz Khan, Deepshikha Gunwan, Nida Khan, Dr. C.K. Tyagi

ABSTRACT

The Present study was to develop and characterize an optimal stable nanosponges of Commiphora angolensis by using the emulsion solvent diffusion method and aimed to increase its bioavailability and release the drug in sustained and controlled manner. The Commiphora angolensis nanosponge was prepared by emulsion solvent diffusion method using different drug-polymer ratios (1:1 to 1:3) Ethyl cellulose and Eudragit are used as a polymer. All formulations evaluated for production yield, entrapment efficiency, In vitro drug release, scanning electron microscopy (SEM) and stability studies. Percentage yield of the prepared Commiphora angolensis Nanosponges was in the range of 58.35±0.82 to 71.53±0.63. Batch F3 showed the highest production yield. The Entrapment efficiency was found to be in the range from 0.579±0.031 to 0.857±0.048 %. It was observed that the encapsulation efficiency depends on the concentration of extract and polymer ratio. On the basis of high yield, and encapsulation efficiency batch F3 was observed as optimized batch for the preparation of Commiphora angolensis Nanosponges. Average particle size of nanoparticles was found to be 729 nm. The zeta potential is defined as the electrical potential between the medium and the layer of the fluid attached to the dispersed particles. Zeta potential of prepared nanoparticles was found -22.8 mV. It was found that higher the zeta potential less will be the particle aggregation, due to electric repulsion and hence more will be the stability of nanoparticles. Formulation F3 release approx 21.37 percent drug within 30 minutes and approx 99.92 percent of drug release in 4 hours. The results of various evaluation parameters, revealed that Commiphora angolensis nanosponges would be possible alternative delivery systems to conventional formulation to improve its bioavailability, the emulsion solvent diffusion method is best method for preparation of nanosponges and release the drug in sustained and controlled manner.

Keywords: Nanosponges, Commiphora angolensis.