Abstract

DEVELOPMENT AND EVALUATION OF NANOPARTICLE DRUG DELIVERY SYSTEMS FOR CEFIXIME TRIHYDRATE

Darshan A.*, Manjunath K., Ashok Kumar P. and Pooja R. V.

ABSTRACT

The aim of the present work was to design Cefixime Trihydrate solid lipid Nano-particles and chitosan nanoparticles and to evaluate them. Cefixime Trihydrate solid lipid Nano-particles were prepared by hot homogenization technique using different lipids (Tristearin and Compritol), soy lecithin as stabilizers and tween 80, Poloxamer as surfactants, and the corresponding chitosan nanoparticles were prepared by ionic gelation method. The Nano-particles were evaluated for particle size & PDI, zeta potential, entrapment efficiency and invitro drug release. The particle size ranged from 46.30 to 690.6nm. PDI was observed within the range of 0.216 to 0.423.The zeta potential ranged from -32.9 to -39.1Mv, Entrapment efficiency was in the range of 75.64 to 94.31 %. The cumulative percentage of drug release varied from 70.67 to 86.41% depending upon the drug lipid ratio and the type of lipid used. The release kinetic studies showed that the release was first order diffusion controlled and the n values obtained from the Korsmeyer-Peppa’s model indicated the release mechanism was Non Fickian super case II type (n-value 1.2). The Chitosan nanoparticles had a mean size of 503.5 To 789.0nm, zeta potential ranged from -4.49 to-6.82 mV, the PDI was in the range of 0.49 to 0.884 and the entrapment efficiency were found to be 71.77-88.61%. The cumulative percentage release of drug varied from 66.38 to 75.65% depending upon the concentration of TPP sodium and acetic acid concentration. The release kinetic studies showed that the release was first order diffusion controlled and the n values obtained from the Korsmeyer-Peppa’s model indicated the release mechanism was Anomalous diffusion(non-Fickian) (n-value 0.640).

Keywords: Cefixime Trihydrate, solid lipid Nano-particles, chitosan nanoparticles, FTIR, in vitro drug release.