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SYNTHESIS AND CHARACTERISATION OF N- ALKYL-2- THIOUREIDO BENZO[d]OXAZOLE-5- CARBOXAMIDES AS ANTIINFLAMMATORY AGENTS
Parvati. S, *Arunadevi Parlapalli, Manasa. Cidda, Sarangapani Manda
ABSTRACT A series of N- alkyl-2-thioureido benzo[d]oxazole-5- carboxamides derivatives were synthesized, characterized by spectral data and were evaluated for anti-inflammatory activity by carragenean induced rat paw odema method at the concentration of 0.1 M and the results were compared with standard Indomethacin at concentration of 0.1M. Among the synthesized compounds,compound VIa (R=methyl), VIe (R=isopropyl) and VIf (R=diisopropyl) were found to be potent. Keywords: carragenean, indomethacin, diisopropyl. [Download Article] [Download Certifiate] |