Abstract

AN OVERVIEW ON PREFORMULATION STUDIES

Abhishek Borkar*, Shubhada Bhopale, Nandkishor Deshmukh, Harish Rathod and Shankar Musale

ABSTRACT

Every drug has intrinsic chemical and physical properties which has been consider before development of pharmaceutical formulation. This property provides the framework for drug‟s combination with pharmaceutical ingredients. Preformulation studies carried out by various research scientists are reviewed. Preformulationstudies conduct for newly synthesized compounds or extracted compound and it gives the information regarding the degradation process, any adverse conditions relevant to the drug, bioavailability, pharmacokinetics and formulation of similar compound and toxicity. Preformulation studies strengthen the scientific foundation of the guidance, provide regulatory relief and conserve resources in the drug development and evaluation process, improve public safety standards, enhance product quality in the fabrication of dosage form.

Keywords: Preformulation, dissolution, oxiadation, computability studies.