Abstract

A COMPREHENSIVE STUDY ON PRINCIPLES OF SUSTAINED RELEASE IN RESPECT TO MATRIX TABLETS

MohammadBhai Revasiya, Jayesh Dwivedi, Ayush Garg* and Rajesh Khathuriya

ABSTRACT

Probably the earliest work in the area of sustained drug delivery dosage forms can be traced from 1938 patent of Israel Lipowski. This work involved coated pellets for prolong release of drug and was presumably the fore runner to the development of the coated particle approach to sustained drug delivery that was introduced in the early 1950’s. There has been 40 years of research and development experience in the sustained release area since that patent, and a number of strategies have been developed to prolong drug levels in the body. These range from the very simple, slowly dissolving pellets or tablets to the technologically sophisticated controlled drug-release systems which have been recently started to appear in the market and in pharmaceutical literature.

Keywords: Sustained release, controlled release, matrix tablet, drug delivery, SR tablet.