Abstract

OVERVIEW ON LIPOSOMAL DRUG DELIVERY

Mansi Bhosale*, Dr. Yadav V.D., Arti Lohar and S. P. Borkar

ABSTRACT

The liposomes were the first Nano medicine to be accepted for clinical use. They are the spherical vesicles that possess mid empty aqueous space, which is encircled by a phospholipids bilayer. Liposomes have immense capability to prevent the degradation of drugs, reduce side effects and are thus increasingly used for targeted drug delivery. The drugs can either be incorporated inside the aqueous space (hydrophilic drugs) or inside the phospholipids bilayer (hydrophobic drugs) of liposomes for the targeted drug delivery. Considering the importance of liposomes as a drug delivery system, the present review paper tries to look into its details. The entire paper is classified into six parts. The first part is introductory. The second part discusses the classification of liposomes. In the third segment, the structural components of liposomes are detailed. The fourth portion of the paper talks about methods of preparation of liposomes. In the fifth segment, the characterization of liposomes is discussed. The sixth part discusses the application of liposomes and the last part is given to concluding observation. Literature shows distinct types of liposomes, categorized based on size, number of lipid layers, composition and preparation method.

Keywords: Phospholipids, Lyophilization, Double emulsion, Solvent dispersion.