Abstract

COMPARISON OF METFORMIN AND METFORMIN WITH OTHER ORAL HYPOGLYCEMIC AGENTS COMBINATION EFFECTS ON WEIGHT IN TYPE-2 DIABETES MELLITUS PATIENTS

Dr. M. Manasa*, S. Radha, S. Mohammad Eliyaz, G. Venkaiah and K. R. Sirisha

ABSTRACT

Metformin shows its side effects like GI disturbances through appetite regulation both directly and indirectly. Mechanism of metformin suppresses appetite and induces weight loss through appetite regulatory path- ways in the brain, with additional effects on adipose and gut-derived signals Many studies support that metformin can promote weight loss in overweight or obesity patients with DM. It is a prospective observational study on metformin induced weight loss conducted for a period of 6 months. totally 78 subjects were invoveld in study and divided them into two groups namely group A (metformin only group) and group B (metformin + other oral hypoglycaemics group). Among them 36 were prescribed with metformin and 42 were prescribed with metformin with other oral hypoglycemic drugs and conclude that subjects who were treated with metformin induced weight loss was high when compared to the patients treated with metformin along with other oral hypoglycemic agents in type-II diabetes. The study showed that six months of metformin monotherapy (500-1000 mg/day) caused a mean reduction in bodyweight of 2-3kgs and weight reduction of 1-3 kgs in patients treated with combination therapy (metformin + other oral hypoglycemic agents) without taking a calorie-restricted diet.

Keywords: Diabetes Mellitus, Obesity, Metformin, Appetite Suppression, Weight Loss.