Abstract

FORMULATION AND PHARMACEUTICAL EVALUATION OF TRAMADOL HYDROCHLORIDE MICROPARTICLE

Anil Pariyar, Shankar Thapa*, Amit Kumar Gupta, Badri Karki and Badal Babu Sharma

ABSTRACT

Conventional dosages form takes several times to absorb and fluctuate the rate of absorption and elimination with concentration versus time curve. It increases the risk of toxicity. These drawbacks can be overcome by sustained/controlled release dosage formulation with the help of the microencapsulation process. The microparticle of Tramadol Hydrochloride was formulated by using the non-solvent addition method. Three batches are formulated using different concentrations of polymers (10%, 20%, and 30% w/v for F1, F2, and F3 batches respectively). The formulation was evaluated for angle of repose, product yield, entrapment efficacy, and in-vitro analysis. The product yield of F1 and F2 batches was found to be 89% and 90% and their angle of repose was reported at 200 and 220 respectively. The entrapment efficacy was found to be better for F2 than the F1 batch. Entrapment efficacy increase with an increase in polymer concentration. From the study, it can be concluded that the release profile of Tramadol Hydrochloride can increase by more than 8 hr by increasing the polymer concentration in the formulation up to the appropriate extent.

Keywords: Microencapsulation, formulation, microparticle, tramadol.