Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL DRUG CONTAINING GRISEOFULVIN

Shriti Kharwar* and Amit Jain

ABSTRACT

Griseofulvin transdermal patches formulated with PEG-400 as plasticizer and polymers HPMC and sodium carboxymethyl cellulose by solvent casting method are quite stable, there is no interaction between drug and formulation component on the basis of physical appearance and FTIR data. The average weight of the patches (2.25 cm2) was found to be ranging from 309 to 314 mg. The thickness of the patches ranged from 0.317 to 0.321 mm and was found to be dependent on the polymer ratio. The patches were able to withstand 62 to 91 folds at same place in the folding endurance test. All the formulations were able to incorporated uniform quantity of drug in them ranging from 97.8 to 99.2 %. The results of moisture content study revealed that increase in concentration of HPMC was directly proportional to the moisture content in the patches with F6 exhibiting the highest moisture (6.93%) while F1 exhibiting the lowest (5.69%). The drug was released ranging from 83.7 to 61.88% in various formulations. The regression coefficients of the graphical representation of the mathematical models reveal that the release of griseofulvin from the patches can be described by Korsemeyer-Peppas model. The expression relates that the drug released from the patches is due to diffusion of drug from the polymeric matrix of the patch and is primarily diffusion controlled.

Keywords: Griseofulvin, Transdermal patches, HPMC, PEG, Plasticizer.