Abstract

PERMEATION ENHANCERS AND MUCOADHESIVE POLYMERS USED IN BUCCAL DRUG DELIVERY SYSTEM: A BRIEF REVIEW

Rachana B. Kamble*, Sadikali F. Sayyad and Apeksha D. Rajguru

ABSTRACT

The buccal area of an oral cavity is an appealing target for administration of the drug of choice, especially in overcoming deficiencies associated with the latter mode of administration. Problems such as excessive first-pass metabolism and drug degradation in the gastrointestinal surroundings can be circumvented through administering the drug with the aid of the buccal route. Moreover, rapid onset of action can be accomplished relative to an oral route and the formulation can be eliminated if therapy is required to be discontinued. Mucoadhesive polymers will increase the residence time, extend the absorption, enhances solubility and dissolution characteristics of poorly soluble drugs. In addition, we are centered on the present-day era of mucoadhesion polymers, led with the aid of the cutting-edge formulation of mucoadhesive for the distribution of oral drugs, such as thiolated polymers. A true perception into mucoadhesion polymers, the mucoadhesive phenomenon and the factors that can have an effect on polymer mucoadhesion is given in the current analysis. This current review provides the advantages, disadvantages of buccal delivery, drug and excipient choice mainly bioadhesive polymers and permeation enhancers. This review additionally covers reachable marketed product and recent patents on buccal drug delivery system and future aspects of buccal drug delivery system.

Keywords: Buccal drug delivey system, mucoadhesive polymer, permeation enhancer, marketed formulations, patents.