Abstract

FORMULATION AND EVALUTION OF HIGH DENSITY MATRIX TABLET OF LANSOPRAZOLE

Surya Bahadur Rajak*, Rajkumar Yadav, Shivanand Patil and Anupriya Adhikari

ABSTRACT

Objective: The aim of present work was to formulate and evaluate high density matrix tablet of lansoprazole, an anti-ulcer drug using natural and synthetic polymers. High density matrix tablets were performed site for sustained release drug action. Methods: Lansoprazole high density matrix tablets were prepared by direct compression. Process with a density increasing agent (Zinc oxide) and various polymers such as HPMC. K15M, Xanthan gum and a combination of both. The prepared tablet was coated by anenteric. Coated polymer of hydroxyl spropyl cellulose phthalate. High density matrix tablets were evaluated by different parameters such as weight variation, drug content, hardness, thickness, density and in-vitro drug release. Results: The drug excipients compatibility study showed no interaction between drug and excipients. The density of tablets was found to be 1.62 gm/cm3, which was higher than the gastric fluid. The formulation F8contains a high density matrix tablet of lansoprazole HPMC K15M, Xanthan gum and combination ratio, which showed an in-vitro drug release of 89.1%. In 8hours. So, it can be concluded that high density matrix tablets of lansoprazole in order to prevent its extensive first pass metabolism and to improve its bioavailability.

Keywords: Lansoprazole, High density Matrix Tablets, Enteric coated matrix tablets, delayed release, HPMC K15M, Xanthan gum.