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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

IDENTIFICATION AND MEDIA OPTIMIZATION OF L-ASPARAGINASE FROM ASPERGILLUS NIGER USING CHEAP RAW MATERIAL AS SUBSTRATE FOR SOLID STATE FERMENTATION

R.D.Shailima Vardhini*

Head, Department of Biochemistry, St. Marys College, Yousufguda, Hyderabad, India.

ABSTRACT

L- Asparaginase (Periplasmic amidohydrolase), E.C. 3.5.1.1 is an enzyme with great biological value. It is used as a drug to cure Acute Lymphoblastic Leukemia (ALL). Besides being used as a drug it is also used as food processing agent. In the present investigation we tried to isolate the fungal organism Aspergillus niger since the fungal microorganisms have always proven to be the most effective sources of L-Asparaginase The enzyme production was enhanced on the cheap raw materials, (OCF) and (CGH) and it was observed that the substrate CGH had showed maximum specific activity.

Keywords: Acute Lymphoblastic leukemia, Aspergillus niger, Cheap raw material, L-Asparaginase, Periplasmic amidohydrolase.

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