Abstract

INVESTIGATION OF ANTIHYPERGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF ETHANOLIC SEED EXTRACT OF ELETTARIA CARDAMOMUM ON ALLOXAN INDUCED DIABETIC RATS

Saikat Ranjan Paul, Tanvirul Haider, Yesmin Begum* and Afifa Parvin Shanta

ABSTRACT

Elettaria cardamomum, commonly known as green or true cardamom, rich in volatile oils and several bioactive compounds, used as spices regularly that contribute to reduce many complications like influenza, infection, asthma, bronchitis, cardiac disorder, diarrhea, nausea, cataracts and many more. Antihyperglycemic and hypolipidemic effects of ethanolic extract of Elettaria cardamomum seeds (EEE) were evaluated in Alloxan induced diabetes in Albino Swiss female rats. The rat models were subjected into five groups as normal control, diabetic control, standard control one (pioglitazone 20 mg/ 70 kg b.w), standard control two (atorvastatin15 mg/ 70 kg b.w) and extract control (200mg/kg). All the rat groups were treated concurrently with 120 mg/kg b.w. of alloxan for 14 days except normal control. Glucose level in fasting condition and body weight of individual rats of all groups had been measured at 5 days interval. Plasma glucose, cholesterol, triglycerides, LDL and HDL from blood sample of all rats were estimated after 14 days. The study results explored that EEE showed statistically significant antihyperglycemic and hypolipidemic effects (p< 0.05) on diabetic models. Green cardamom which is a famous spice had been proved to have various phytochemicals responsible for the biological activity that necessitate the chemical identification in future.

Keywords: Antihyperglycemia, hypolipidemic, Elettaria cardamomum, Alloxan, type-2 diabetes.