Abstract

INVESTIGATION OF HEPATOPROTECTIVE ACTIVITY OF GUAVALEAF EXTRACT AGAINST ANTI-TUBERCULAR DRUG INDUCED HEPATOTOXICITY IN ALBINO WISTAR RAT

*Urja Kumari, Dileep Kumar, Jayesh Dwivedi, Ayush Garg, Ranu Sharma, Vijay Singh Kachawa, Ravisha Suthar and Ajaz Bhatt

ABSTRACT

The study was designed to investigation of hepatoprotective activity of guava leaf extract against anti-tubercular drug induced hepatotoxicity in albino wistar rat. The effects observed were compared with a known hepatoprotective agent, silymarin. In the acute liver damage induced by different hepatotoxins, guava leaf extract (250 and 500mg/kg) significantly reduced the elevated serum level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphate and bilirubin. The higher dose of the extract (500mg/kg) prevented the increase in liver weight when compared with hepatoxin treated control, while the lower dose was ineffective. Histological examination of the liver tissues supported the hepatoprotection. It is concluded that the aqueous extract of leaves of guava plant possess good hepatoprotective activity.

Keywords: Hepatoprotection, Guava (P. guajava).