Abstract

UV - VIS SPECTROSCOPY METHOD TO DETERMINATION AND VALIDATION OF TICAGRELOR IN BULK AND PHARMACEUTICAL DOSAGE FORM

Pramod Sarraf*, Chandanam Sreedhar, T. Srinivasa Rao, Harsha K. Tripathy, Deepthi D. Kini, Preksha Adhikari

ABSTRACT

The spectroscopic method for the Ticagrelor bulk drug and pharmaceutical dosage form was developed using methanol as a solvent. The method's linearity was determined by evaluating analyte concentrations ranging from 10mcg/ml to 60mcg/ml. The interday and intraday precision was tested six times (for two days), and the results obtained within and between trial days were expressed as % RSD. The method holds good linearity from 10-60mcg/ml. The %RSD values of precision studies were found to be below the accepted limit of 2%. The method was found to be linear with a correlation coefficient (R2) of 0.9972. The method was also found to be accurate and robust with suitable values. The results of the study indicated that this method can be used to determine Ticagrelor in bulk medicine and pharmaceutical dosage forms on a regular basis.

Keywords: Ticagrelor, UV Spectroscopy, Validation, Linearity.