Abstract

A SHORT REVIEW ON TARGATED DRUG DELIVERY SYSTEM

Jyoti Kumari*, Hariom Sharma, Gaurav Kumar Sharma and Kaushal Kishor Chandrul

ABSTRACT

(1) Targeted drug delivery system means to selectively transport drugs to targeted tissues, organs and cells through a variety of drugs carrier. (2) Drug targeting is new delivery system that aims to deliver the drug to the target site of action or site of absorption without releasing the drug at any other non-target site. (3) The delivery system is designed to retain the intact drug without any modification until reaching and releasing at target site. (4) The TDDS have several advantages over conventional ones as improvement of pharmaceutical activity, low side effects and reduction of the administered dose. (5) The main purpose of the TDDS is to obtain the pharmacological action of the therapeutic agent at diseased organs only without affecting the healthy one especially in the case of cancer treatment with chemotherapeutic agents. (6) The drug targeting is a useful delivery system for delivering the therapeutic agent to a specific site without causing toxicity in other organs. (7) The evolution of these new approaches plays a vital role in the treatment of chronic diseases like diabetes, tumors and cancers, etc. (8) Various drug carriers that are in advanced delivery systems are soluble polymers, inorganic nanoparticles, magnetic nanoparticles, biodegradable microsphere polymers, neutrophils, fibroblasts, artificial cells, lipoproteins, liposomes, micelles and immune micelle. (9) In selecting such a vehicle, important factors to consider are chemical and physical properties drugs, side effect to healthy cells, route to be taken for delivery of the drug, the targeted site and the disease. (10) As such, TDD formulations are prepared by considering the specific properties of target cells, nature of transport carriers, which convey drug to specific receptors and ligand and physically modulated components. (11) Basically, targeted drug delivery is to assist the drug molecule to reach preferably to desired site. (12) The inherent advantage of this technique leads to administration of required drug with its reduced dose and reducedits side effect. (13) This inherent advantage of targeted drug delivery system is under high consideration of research and development in clinical and pharmaceutical fields as backbone of therapeutic and diagnostic too. (14) The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue.

Keywords: Targeted drug delivery, Introduction, Carriers, Liposome, Nanoparticles, Microspheres, Monoclonal antibody.