Abstract

FORMULATION AND EVALUATION OF POSACONAZOLE GEL FOR THE TREATMENT OF FUNGAL INFECTIONS

Ramesh Kumar Chaurasiya*, Dr. Sowjanya Battu, Dr. B. A. Vishwanath and Girindra Lekhi

ABSTRACT

Antifungal drugs are frequently chosen as the preferred method of delivery for treating infections. The main objective of conventional drug delivery systems is to improve the pharmacokinetic and pharmacodynamic properties of the drug molecule, either by employing a variety of techniques or by altering the structure of the drug molecule. The process through which topical gel can permeate the skin and treat infections is better understood thanks to this study. The most innovative and promising method of medicine delivery is a topical gel. It affects the drug's slow rate of absorption through the skin layers and how quickly it leaves the skin. Numerous topical gels have been studied for their advantages and disadvantages. Posaconazole is a substituted imidazole antifungal specialist with poor solubility and high permeability that is a member of the BCS Class II class family. Posaconazole displays broad-spectrum efficacy against dimorphic organisms, and certain gram-positive bacteria, including dermatophytes, molds, and yeasts. After topical administration, it is a highly lipophilic medication with a short half-life (15-35h) and negligible gastrointestinal absorption (0.6 percent of an applied portion).

Keywords: Permeation enhancement, Topical gel, Hydrogel, Cross-linking, Topical routes.