Abstract

A REVIEW ON SPRAY CONGEALING: AN INNOVATIVE TECHNOLOGY FOR NOVEL DRUG DELIVERY SYSTEMS

Apeksha D. Rajguru*, Sadikali F. Sayyad, Rachana B. Kamble and Jayesh R. Nikam

ABSTRACT

Poor solubility and bioavailability of a current or newly synthesized drug constantly pose undertaking in the improvement of environment-friendly pharmaceutical formulation. The potential of spray congealing in microencapsulation, taste-masking and controlled release was once explored and in contrast to different generally used technologies, particularly spray drying and hot melt extrusion. The capability to manage powder characteristics except the need of subsequent downstream processing techniques is a marked benefit over different ―particle engineering‖ technologies. Current review deals with the significance of spray congealing technology in drug delivery, essentially for solubility and bioavailability enhancement, with a focus on the mechanisms underpinning the bioavailability enhancement. Finally, this work offers precise insights on the predominant factors to be viewed for the manufacturing and characterization of spray congealed solid microparticles.

Keywords: Spray congealing, Spray chilling, Spray Prilling, Spray cooling, Microencapsulation Techniques.