Abstract

A REVIEW ON DEVELOPMENT AND ESTIMATION OF MUCOADHESIVE PATCHES OF GABAPENTIN

Kirti Shukla* and Abadhesh Niranjan

ABSTRACT

As taking drugs orally is generally advised, there are several disadvantages, including hepatic pre-systemic metabolism, gastrointestinal disruption, and enzyme degradation. A method that delivers medications in the systemic circulation and avoids the pre-systemic metabolism, such as intranasal, buccal, transdermal, and pulmonary routes, came into awareness to address these issues. This review deals with literature inclusion from the PubMed, Scopus, Web of Science and other reputed platforms. This article focuses on the polymers utilized in mucoadhesive formulation, cohesion mechanisms, primary preparation methods (solvent casting & milling), and benefits & drawbacks of mucoadhesive patches. A muco-adhesion is described as an interfacial adhesion in which a force of attraction holds one artificial mucoadhesive polymer and the opposing mucin layer (mucosal tissue) together. Mucoadhesive patches are formulated by milling method & solvent casting method. Patches are estimated for different parameters such as thickness & weight variation, surface pH, In-vitro drug release, % drug content, swelling index, folding endurance, mucoadhesive strength & stability. It has numerous advantages over other routes of administration with few drawbacks. The following disorders are frequently linked to neuropathic pain: postherpetic neuralgia, trigeminal neuralgia, painful radiculopathy, leprosy, HIV infection, and diabetic neuropathy. Antiepileptic drug gabapentin has enticing pharmacokinetic features as well as a mystery mechanism of action that differs significantly from other anti-epileptic medications. Gabapentin has a wide range of pharmacokinetic and pharmacodynamic properties.

Keywords: Mucoadhesive patch, Solvent casting, Milling, Neuropathic pain, Gabapentin.