Abstract

NIOSOMES AS NOVEL DRUG DELIVERY SYSTEM: A REVIEW

Harish Rathod*, Shubhada Bhopale, Bhaskar Ambhore, Ravikiran More and Mahesh Kekan

ABSTRACT

Niosome are non-ionic surfactant vesicles obtained by hydrating mixture of cholesterol and non-ionic Surfactants. It can be used as carriers of amphiphilic and lipophilic drug. In Niosomes drug delivery system, the medication is encapsulated in a vesicle. Niosomes are biodegradable, biocompatible non-immunogenic and exhibit flexibility in their structural characterization. The main object of this review the application of noisome technology is used to treat a number of diseases, Niosome have good opportunity in research and beneficial for researcher and pharma industries. Niosome appears to be a well preferred drug delivery system over liposome as niosome being stable and economic. Also niosomes have great drug delivery potential for targeted delivery of anti-cancer, anti-infective agents. Drug delivery potential of niosome can enhances by using novel drug delivery concepts like proniosomes, discomes and aspasome. Niosomes also serve better aid in diagnostic imaging and as A vaccine adjuvant. Thus these areas need further exploration and research so as to bring out or to make for commercially available niosomal preparation.

Keywords: Niosomes, Compositions, Methods of Preparation, Encapsulation, Surfactants, Vesicles and Applications.